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Synthesis, structure-activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists.

Bioorganic & medicinal chemistry letters 2005 Sep 1; 15(17):3870-3

Link to PubMed abstract

Han X X, Michne J JA, Pin S SS, Burris K KD, Balanda L LA, Fung L LK, Fiedler T T, Browman K KE, Taber M MT, Zhang J J, Dubowchik G GM

Pharmaceutical Research Institute, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, CT 06492, USA. xiaojun.han@bms.com

7-Aryl-6,7-dihydroimidazoimidazoles represent a novel series of high-affinity corticotropin-releasing factor 1 receptor antagonists. Here, we report their synthesis and SAR as well as behavioral activity of two exemplary compounds, 7b and 7k, in a mouse canopy model of anxiety.