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Pyrimidine containing RSV fusion inhibitors.

Bioorganic & medicinal chemistry letters 2005 Jan 17; 15(2):427-30

Link to PubMed abstract

Nikitenko A A, Raifeld Y Y, Mitsner B B, Newman H H

Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Rd, Pearl River, NY 10965, USA. nikitea@wyeth.com

The knowledge of SAR in a series of biphenyl anionic RSV inhibitors has been broadened by synthesis and testing of analogs with pyrimidine linkers. Generally, pyrimidine compounds were much harder to synthesize, and their anti-RSV activity was lower in comparison with triazine analogs.