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Anti-coxsackievirus B3 activity of 2-amino-3-nitropyrazolo[1,5-a]pyrimidines and their analogs.

Bioorganic & medicinal chemistry letters 2005 Jan 3; 15(1):37-9

Link to PubMed abstract

Makarov V VA, Riabova O OB, Granik V VG, Dahse H HM, Stelzner A A, Wutzler P P, Schmidtke M M

Department of Medicinal Chemistry, Research Center for Antibiotics, 3a Nagatinskaya str., Moscow 117105, Russia.

A novel class of 2-amino-4-nitropyrazolo[1,5-a]pyrimidines has been identified as potent inhibitors of coxsackievirus B3 replication. The synthesis of these compounds is based on the regioselective reaction of 3,5-diamino-5-nitropyrazole with unsymmetrical beta-diketones at catalysis by hydrochloric acid leading to 2-amino-4-nitropyrazolo[1,5-a]pyrimidines as key steps.