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Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas.

Bioorganic & medicinal chemistry letters 2005 Jan 3; 15(1):25-8

Link to PubMed abstract

Burrows J JN, Cumming J JG, Fillery S SM, Hamlin G GA, Hudson J JA, Jackson R RJ, McLaughlin S S, Shaw J JS

Respiratory and Inflammation Research Area, AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire, SK10 4TG, UK.

Investigation of weak screening hits led to the identification of N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides and N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-N'-benzylureas as potent, selective ligands for the human CCR5 chemokine receptor.