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Ligand discovery using small molecule microarrays.

The Journal of pharmacology and experimental therapeutics 2005 Apr 1; 313(1):1-7

Link to PubMed abstract

He X XG, Gerona-Navarro G G, Jaffrey S SR

Department of Pharmacology, Weill Medical College, Cornell University, 1300 York Avenue, Box 70, New York, NY 10021, USA.

Small molecule microarrays have recently been used to identify ligands for several proteins, and several themes regarding screening strategies and limitations have emerged. In this review, some of the technical issues related to the manufacture and screening of small molecule microarrays, as well as prospects for small molecule microarrays in several areas of drug discovery and chemistry, are discussed.