See today's edition of
DailyUpdates in your
therapeutic area
Search all articles

Keywords:

Boolean terms AND, OR, NOT can be used. Phrases should be entered within quotes. For wildcards use an *

Synthesis of N3,5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, a novel compound with anti-hepatitis C virus activity.

Journal of medicinal chemistry 2004 Nov 18; 47(24):6100-3

Link to PubMed abstract

Wang P P, Hollecker L L, Pankiewicz K KW, Patterson S SE, Whitaker T T, McBrayer T TR, Tharnish P PM, Sidwell R RW, Stuyver L LJ, Otto M MJ, Schinazi R RF, Watanabe K KA

Pharmasset Inc., Tucker, Georgia 30084, Utah State University, Logan, Utah 84322, USA. pwang@pharmasset.com

A novel anti-hepatitis C virus (HCV) agent, N(3),5'-cyclo-4-(beta-D-ribofuranosyl)-vic-triazolo[4,5-b]pyridinin-5-one, was identified, and the structure was confirmed by chemical synthesis from 2-hydroxy-5-nitropyridine.