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Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressants.

Bioorganic & medicinal chemistry 2004 Aug 1; 12(15):4189-96

Link to PubMed abstract

Bhandari K K, Srivastava S S, Shankar G G

Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow 226001, India. bhandarikalpana@rediffmail.com

A series of thiourea derivatives (7-23, 25-27) of 1-aminotetrahydronaphthalene (4) and 1-amino-2-hydroxytetrahydronaphthalene (5) were synthesized in single pot in 48-90% yield and evaluated for their anorexigenic activity. Among them compounds 10, 14, 15, 16 and 22 exhibited significant anorexigenic activity without any antidepressant effect and provided a new structural lead for appetite suppressants.