Today's journal articles

Meta-analysis of the relations of anxiety sensitivity to the depressive and anxiety disorders.

Do you need further information on any of the agents being evaluated in the trial(s) below?  Let us know...

New Clinical Trials

A Trial Evaluating the Efficacy and Tolerability of SSR125543 in Outpatients With Major Depressive Disorder (AGATE)

Previous Journal Entries

Pharmacological characterization of a novel positive modulator at alpha(4)beta(3)delta-containing extrasynaptic GABA(A) receptors.

Synthesis and pharmacological evaluation of new 5 - (cyclo)alkyl - 5 - phenyl - and 5 - spiroimidazolidine - 2,4 - dione derivatives. Novel 5 - HT(1A) receptor agonist with potential antidepressant and anxiolytic activity.

Antidepressant-like effects of an AMPA receptor potentiator under a chronic mild stress paradigm.

F15599, a highly selective post-synaptic 5-HT1A receptor agonist: in-vivo profile in behavioural models of antidepressant and serotonergic activity.

Do atypical antipsychotic drugs reduce the risk of ischemic heart disease and mortality? Possible role of 5-HT2A receptor blockade.

Design, Synthesis, Biological Properties, and Molecular Modeling Investigations of Novel Tacrine Derivatives with a Combination of Acetylcholinesterase Inhibition and Cannabinoid CB(1) Receptor Antagonism.

Switching stable patients with schizophrenia from depot and oral antipsychotics to long-acting injectable risperidone: reasons for switching and safety.

Benzimidazole - and indole - substituted 1,3' - bipyrrolidine benzamides as histamine H(3) receptor antagonists.

Predictive screening model for potential vector - mediated transport of cationic substrates at the blood - brain barrier choline transporter.

Synthesis of Dihydrofuroaporphine Derivatives: Identification of a Potent and Selective Serotonin 5 - HT(1A) Receptor Agonist.

Effect of the selective norepinephrine reuptake inhibitor reboxetine on cognitive dysfunction in schizophrenia patients: an add-on, double-blind placebo-controlled study.

Antipsychotic-like effects of the N-methyl-D-aspartate receptor modulator neboglamine: an immunohistochemical and behavioural study in the rat.

Synthesis and structural and pharmacological properties of cyclopropane - based conformationally restricted analogs of 4 - methylhistamine as histamine H(3)/H(4) receptor ligands.

Oxime Carbamate - Discovery of a series of novel FAAH inhibitors.

Double-blind comparison of 30 and 60 mg tranylcypromine daily in patients with panic disorder comorbid with social anxiety disorder.

Discovery of 4 - (5 - Methyloxazolo[4,5 - b]pyridin - 2 - yl) - 1,4 - diazabicyclo[3.2.2]nonane (CP - 810,123), a Novel alpha7 Nicotinic Acetylcholine Receptor Agonist for the Treatment of Cognitive Disorders in Schizophrenia: Synthesis, SAR Development, and in Vivo Efficacy in Cognition Models.

A 6-week, randomized, double-blind, placebo-controlled study of the efficacy and safety of risperidone in adolescents with schizophrenia.

A Multicenter, Placebo-Controlled, Double-Blind, Randomized Study of Efficacy and Safety of Ocinaplon (DOV 273,547) in Generalized Anxiety Disorder.

Synthesis and antidepressant activity of optical isomers of 2 - (4 - benzylpiperazin - 1 - yl) - 1 - (5 - chloro - 6 - methoxynaphthalen - 2 - yl) propan - 1 - ol (SIPI5056).

Characterization of a novel non-steroidal glucocorticoid receptor antagonist.

Today's News Items

IntelGenx Receives FDA Complete Response Letter CPI-300

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