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Today's headline articles

Sofosbuvir for Previously Untreated Chronic Hepatitis C Infection.

Today's journal articles

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Do you need further information on any of the agents being evaluated in the trial(s) below?  Let us know...

New Clinical Trials

Immune Activation and Drug Absorption in HIV-Infected Patients

Previous Journal Entries

Potential role of tedizolid phosphate in the treatment of acute bacterial skin infections.

Novel, anionic, anti-viral septapeptides from mosquito cells also protect monkey cells against Dengue virus.

Development of cellular signaling pathway inhibitors as new antivirals against influenza.

Design and evaluation of substrate-based octapeptide and non substrate-based tetrapeptide inhibitors of dengue virus NS2B-NS3 proteases.

Synthesis of cephalosporin-3'-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase.

Antiviral therapy of symptomatic HCV-associated mixed cryoglobulinemia: Meta-analysis of clinical studies.

Synthesis, characterization, in vitro antimicrobial, and U2OS tumoricidal activities of different coumarin derivatives.

Staphylococcus aureus supernatant induces the release of mouse β-defensin-14 from osteoblasts via the p38 MAPK and NF-κB pathways.

A small molecule inhibitor of fungal histone acetyltransferase Rtt109.

Optical coherence tomography for assessment of microbicide safety in a small animal model.

Synthesis and antimicrobial activity of novel amphiphilic aromatic amino alcohols.

MicroRNA-21 and -146b are involved in the pathogenesis of murine viral myocarditis by regulating TH-17 differentiation.

The putative JAK-STAT inhibitor AG490 exacerbates LPS-fever, reduces sickness behavior, and alters the expression of pro- and anti-inflammatory genes in the rat brain.

BLIP-II is a highly potent inhibitor of Klebsiella pneumonia carbapenemase (KPC-2).

In vitro Activity of Doripenem plus Fosfomycin against Drug-Resistant Clinical Blood Isolates.

A Role for Protein Phosphatase 2A in Regulating p38 Mitogen Activated Protein Kinase Activation and Tumor Necrosis Factor-Alpha Expression during Influenza Virus Infection.

Syntheses and evaluation of macrocyclic engelhardione analogs as antitubercular and antibacterial agents.

Small Interfering RNA Targeting Toll-Like Receptor 9 Protects Mice against Polymicrobial Septic Acute Kidney Injury.

Identification and Characterization of a Novel HIV-1 Nucleotide Competing RT Inhibitor Series.

Benchmarking CIN 3+ Risk as the Basis for Incorporating HPV and Pap Cotesting into Cervical Screening and Management Guidelines.

Today's News Items

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Training Courses & Meetings

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Previous News Items

U.S. FDA Grants Priority Review to Simeprevir (TMC435) for Combination Treatment of Genotype 1 Chronic Hepatitis C

Ligand Partner Rib-X Initiates Phase 3 Trial of Captisol-enabled™ Delafloxacin IV