Today's headline articles

Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.

Today's journal articles

Inhibition of Inflammatory Cytokine Production from Rheumatoid Synovial Fibroblasts by a Novel I{kappa}B Kinase Inhibitor.

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New Clinical Trials

A Study To Examine The Safety, Pharmacokinetics And Pharmacodynamics Of PF-03635659 In Patients With Chronic Obstructive Pulmonary Disease

Characterization of 24 Hour Spirometry Profiles of Inhaled BI 1744 CL and Inhaled Tiotropium Bromide in Patients With Chronic Obstructive Pulmonary Disease

The Effect Of PF-03654764 +/- Allegra On Symptoms Of Allergic Rhinitis

Previous Journal Entries

Pharmacological Profile of the Novel Anti-inflammatory Corticosteroid NS-126, a Therapeutic Agent for Allergic Rhinitis.

A Randomized, Controlled, Phase 2 Study of AMG 317, an IL-4R{alpha} Antagonist, in Patients with Asthma.

Role of Low-Affinity Nerve Growth Factor Receptor Inhibitory Antibody in Reducing Pain Behavior and Calcitonin Gene-Related Peptide Expression in a Rat Model of Wrist Joint Inflammatory Pain.

Synthesis and optimization of hyaluronic acid - methotrexate conjugates to maximize benefit in the treatment of osteoarthritis.

Novel 3 - aminopyrazole inhibitors of MK - 2 discovered by scaffold hopping strategy.

Inhibition of Glycogen Synthase Kinase 3{beta} (GSK3{beta}) Decreases Inflammatory Responses in Brain Endothelial Cells.

Partial and transient modulation of the CD3-T-cell receptor complex, elicited by low-dose regimens of monoclonal anti-CD3, is sufficient to induce disease remission in non-obese diabetic mice.

Prevention and treatment of experimental autoimmune encephalomyelitis with clonotypic CDR3 peptides: CD4(+) FoxP3(+) T-regulatory cells suppress interleukin-2-dependent expansion of myelin basic protein-specific T cells.

Acceptability of switching adalimumab from a prefilled syringe to an autoinjection pen.

Discovery of 3 - (4 - bromophenyl) - 6 - nitrobenzo[1.3.2]dithiazolium ylide 1,1 - dioxide as a novel dual cyclooxygenase/5 - lipoxygenase inhibitor that also inhibits tumor necrosis factor - alpha production.

Interleukin-4 inhibits an early phase in the HIV-1 life cycle in the human colorectal cell line HT-29.

Inhibition of PI3K by PX-866 Prevents Transforming Growth Factor-{alpha}-Induced Pulmonary Fibrosis.

Novel effects mediated by bradykinin and pharmacological characterization of bradykinin B2 receptor antagonism in human synovial fibroblasts.

Effect of the C3a-Receptor Antagonist SB 290157 on Anti-OVA Polyclonal Antibody-Induced Arthritis.

Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis.

Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis.

Improved adherence with once-daily versus twice-daily dosing of mometasone furoate administered via a dry powder inhaler: a randomized open-label study.

Anti-TNF-alpha agents are less effective for the treatment of rheumatoid arthritis in current smokers.

Soluble CD40 ligand impairs the function of peripheral blood angiogenic outgrowth cells and increases neointimal formation after arterial injury.

Metformin inhibits inflammatory angiogenesis in a murine sponge model.

Today's News Items

Anthera Pharmaceuticals Announces Agreement with the FDA on a SPA for Planned Phase 3 Varespladib A-002 Study

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Previous News Items

Teva Announces FDA Accepts BLA for XM02

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