DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery

Rationale and design of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial: A randomized controlled study of spironolactone in patients with symptomatic heart failure and preserved ejection fraction.

Thu, 09 Feb 2012 21:56:52 GMT

Rationale and design of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial: A randomized controlled study of spironolactone in patients with symptomatic heart failure and preserved ejection fraction....Read More

Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia.

Thu, 09 Feb 2012 21:56:52 GMT

Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia....Read More

Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in rats.

Thu, 09 Feb 2012 21:56:52 GMT

Blockade of dopamine d4 receptors attenuates reinstatement of extinguished nicotine-seeking behavior in rats....Read More

Quitting smoking with varenicline: parallel randomised efficacy trial in Iran.

Thu, 09 Feb 2012 21:56:52 GMT

Quitting smoking with varenicline: parallel randomised efficacy trial in Iran....Read More

() - 2 - (N - tert - Butylamino) - 3 - (125)I - iodo - 4 - azidopropiophenone: A dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin Zyban).

Thu, 09 Feb 2012 21:56:52 GMT

() - 2 - (N - tert - Butylamino) - 3 - (125)I - iodo - 4 - azidopropiophenone: A dopamine transporter and nicotinic acetylcholine receptor photoaffinity ligand based on bupropion (Wellbutrin Zyban)....Read More

Symptomatic Hyperbilirubinemia Secondary to Dapsone Induced Hemolysis and Atazanavir Therapy.

Thu, 09 Feb 2012 21:56:52 GMT

Symptomatic Hyperbilirubinemia Secondary to Dapsone Induced Hemolysis and Atazanavir Therapy....Read More

Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E(2) synthase - 1 inhibitors.

Thu, 09 Feb 2012 21:56:52 GMT

Synthesis and SAR study of imidazoquinolines as a novel structural class of microsomal prostaglandin E(2) synthase - 1 inhibitors....Read More

Discovery and optimization of thieno23 - dpyrimidines as B - Raf inhibitors.

Thu, 09 Feb 2012 21:56:52 GMT

Discovery and optimization of thieno23 - dpyrimidines as B - Raf inhibitors....Read More

Does Severe Anemia Caused by Dose-Dense Paclitaxel-Carboplatin Combination Therapy Have an Effect on the Survival of Patients With Epithelial Ovarian Cancer Retrospective Analysis of the Japanese Gynecologic Oncology Group 3016 Trial.

Thu, 09 Feb 2012 21:56:52 GMT

Does Severe Anemia Caused by Dose-Dense Paclitaxel-Carboplatin Combination Therapy Have an Effect on the Survival of Patients With Epithelial Ovarian Cancer Retrospective Analysis of the Japanese Gynecologic Oncology Group 3016 Trial....Read More

Design and diversity - oriented synthesis of novel 14 - thiazepan - 3 - ones fused with bioactive heterocyclic skeletons and evaluation of their antioxidant and cytotoxic activities.

Thu, 09 Feb 2012 21:56:52 GMT

Design and diversity - oriented synthesis of novel 14 - thiazepan - 3 - ones fused with bioactive heterocyclic skeletons and evaluation of their antioxidant and cytotoxic activities....Read More

A Novel Function of p38-RegulatedActivated Kinase (PRAK) In Endothelial Cell Migration and Tumor Angiogenesis.

Thu, 09 Feb 2012 21:56:52 GMT

A Novel Function of p38-RegulatedActivated Kinase (PRAK) In Endothelial Cell Migration and Tumor Angiogenesis....Read More

Amgen to Discuss Application for New Use of XGEVA (denosumab) at FDA Oncologic Drugs Advisory Committee Meeting

Thu, 09 Feb 2012 21:56:53 GMT

Amgen to Discuss Application for New Use of XGEVA (denosumab) at FDA Oncologic Drugs Advisory Committee Meeting...Read More

Forest Laboratories Inc. and Gedeon Richter Plc Announce Positive Phase III Results with the Investigational Antipsychotic Cariprazine in Patients with Acute Mania Associated with Bipolar I Disorder

Thu, 09 Feb 2012 21:56:53 GMT

Forest Laboratories Inc. and Gedeon Richter Plc Announce Positive Phase III Results with the Investigational Antipsychotic Cariprazine in Patients with Acute Mania Associated with Bipolar I Disorder...Read More

BioSante Pharmaceuticals Reports Positive LibiGel Safety Data Review for Phase III Program

Thu, 09 Feb 2012 21:56:53 GMT

BioSante Pharmaceuticals Reports Positive LibiGel Safety Data Review for Phase III Program...Read More

FDA Sets Shortcut Path for Biosimilar Drugs

Thu, 09 Feb 2012 21:56:53 GMT

FDA Sets Shortcut Path for Biosimilar Drugs...Read More

OptiNose Files Investigational New Drug Application to use Sumatriptan Delivered with its Novel Drug Delivery Technology

Thu, 09 Feb 2012 21:56:53 GMT

OptiNose Files Investigational New Drug Application to use Sumatriptan Delivered with its Novel Drug Delivery Technology...Read More

Nesiritide in Resistant Hypertension

Thu, 09 Feb 2012 21:56:54 GMT

Nesiritide in Resistant Hypertension...Read More

A Study to Evaluate the PKPD and Safety of TA-7284 in Patients With Type 2 Diabetes Mellitus Who Have Moderate Renal Impairment

Thu, 09 Feb 2012 21:56:54 GMT

A Study to Evaluate the PKPD and Safety of TA-7284 in Patients With Type 2 Diabetes Mellitus Who Have Moderate Renal Impairment...Read More

An Efficacy and Safety Study of Telaprevir in Patients Infected With Both Chronic HCV-1 and HIV-1

Thu, 09 Feb 2012 21:56:54 GMT

An Efficacy and Safety Study of Telaprevir in Patients Infected With Both Chronic HCV-1 and HIV-1...Read More

Pharmacokinetics of Vancomycin for Inhalation in Cystic Fibrosis

Thu, 09 Feb 2012 21:56:54 GMT

Pharmacokinetics of Vancomycin for Inhalation in Cystic Fibrosis...Read More

A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002)

Thu, 09 Feb 2012 21:56:54 GMT

A Study of MK-6072 and MK-3415A in Participants Receiving Antibiotic Therapy for Clostridium Difficile Infection (MK-3415A-002)...Read More

Safety Tolerability and Pharmacokinetics of SAR113945 in Japanese Patients With Knee Osteoarthritis

Thu, 09 Feb 2012 21:56:54 GMT

Safety Tolerability and Pharmacokinetics of SAR113945 in Japanese Patients With Knee Osteoarthritis...Read More

Phase I Intratumoral Pbi-shRNA STMN1 LP in Advanced andor Metastatic Cancer

Thu, 09 Feb 2012 21:56:54 GMT

Phase I Intratumoral Pbi-shRNA STMN1 LP in Advanced andor Metastatic Cancer...Read More

Safety and PK Study of RRx-001 in Cancer Subjects

Thu, 09 Feb 2012 21:56:54 GMT

Safety and PK Study of RRx-001 in Cancer Subjects...Read More

Docetaxel and Lapatinib in Metastatic Transitional Cell Carcinoma in Bladder

Thu, 09 Feb 2012 21:56:54 GMT

Docetaxel and Lapatinib in Metastatic Transitional Cell Carcinoma in Bladder...Read More

CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors

Thu, 09 Feb 2012 21:56:54 GMT

CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors...Read More

Psoriasis Therapeutics - Pipeline Assessment and Market Forecasts to 2018

Thu, 09 Feb 2012 21:56:54 GMT

Psoriasis Therapeutics - Pipeline Assessment and Market Forecasts to 2018...Read More

Type 1 Diabetes Therapeutics - Pipeline Assessment and Market Forecasts to 2018

Thu, 09 Feb 2012 21:56:54 GMT

Type 1 Diabetes Therapeutics - Pipeline Assessment and Market Forecasts to 2018...Read More

Glioblastoma Multiforme (GBM) Therapeutics - Pipeline Assessment and Market Forecasts to 2018

Thu, 09 Feb 2012 21:56:54 GMT

Glioblastoma Multiforme (GBM) Therapeutics - Pipeline Assessment and Market Forecasts to 2018...Read More

Depression Therapeutics - Pipeline Assessment and Market Forecasts to 2018

Thu, 09 Feb 2012 21:56:54 GMT

Depression Therapeutics - Pipeline Assessment and Market Forecasts to 2018...Read More