DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery http://www.leaddiscovery.co.uk Dedicated to drug discovery, LeadDiscovery was founded in 1998 by life scientists for life scientists. Tue, 06 Jan 2009 17:31:12 GMT DailyUpdates http://www.leaddiscovery.co.uk Breaking Research, Development News and Pharmareports for Drug Discovery http://www.leaddiscovery.co.uk/dailyupdates_RSS_Icon.gif 144 59 http://www.leaddiscovery.co.uk/articles/18990569/dailyupdate?1 http://www.leaddiscovery.co.uk/articles/18990569/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Structure - activity relationships of 3 - substituted N - benzhydryl - nortropane analogs as nociceptin receptor ligands for the treatment of cough. http://www.leaddiscovery.co.uk/articles/19010927/dailyupdate?2 http://www.leaddiscovery.co.uk/articles/19010927/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Effect of fenretinide and low-dose tamoxifen on insulin sensitivity in premenopausal women at high risk for breast cancer. http://www.leaddiscovery.co.uk/articles/18976929/dailyupdate?3 http://www.leaddiscovery.co.uk/articles/18976929/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor. http://www.leaddiscovery.co.uk/articles/18987875/dailyupdate?4 http://www.leaddiscovery.co.uk/articles/18987875/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Dynamic imaging of cancer growth and invasion: a modified skin - fold chamber model. http://www.leaddiscovery.co.uk/articles/19010871/dailyupdate?5 http://www.leaddiscovery.co.uk/articles/19010871/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Phase I Study of Copper-Binding Agent ATN-224 in Patients with Advanced Solid Tumors. http://www.leaddiscovery.co.uk/articles/19006566/dailyupdate?6 http://www.leaddiscovery.co.uk/articles/19006566/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells. http://www.leaddiscovery.co.uk/articles/19009247/dailyupdate?7 http://www.leaddiscovery.co.uk/articles/19009247/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Tissue Microarray Analysis of 560 Patients with Colorectal Adenocarcinoma: High Expression of HuR Predicts Poor Survival. http://www.leaddiscovery.co.uk/articles/18989950/dailyupdate?8 http://www.leaddiscovery.co.uk/articles/18989950/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT A Small Molecule Inhibitor 1245 - Benzenetetraamine Tetrahydrochloride Targeting the Y397 Site of Focal Adhesion Kinase Decreases Tumor Growth. http://www.leaddiscovery.co.uk/articles/19007111/dailyupdate?9 http://www.leaddiscovery.co.uk/articles/19007111/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Novel Multifunctional Acyloxyalkyl Ester Prodrugs of 5 - Aminolevulinic Acid Display Improved Anticancer Activity Independent and Dependent on Photoactivation. http://www.leaddiscovery.co.uk/articles/19010543/dailyupdate?10 http://www.leaddiscovery.co.uk/articles/19010543/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Induction of apoptosis in leukemic cell lines treated with captopril trandolapril and losartan: A new role in the treatment of leukaemia for these agents. http://www.leaddiscovery.co.uk/articles/19014997/dailyupdate?11 http://www.leaddiscovery.co.uk/articles/19014997/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Estrone C15 derivatives-A new class of 17beta-hydroxysteroid dehydrogenase type 1 inhibitors. http://www.leaddiscovery.co.uk/articles/18990168/dailyupdate?12 http://www.leaddiscovery.co.uk/articles/18990168/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Systemic therapy for advancing or metastatic prostate cancer (STAMPEDE): a multi-arm multistage randomized controlled trial. http://www.leaddiscovery.co.uk/articles/19010869/dailyupdate?13 http://www.leaddiscovery.co.uk/articles/19010869/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Bortezomib-mediated inhibition of steroid receptor coactivator-3 degradation leads to activated akt. http://www.leaddiscovery.co.uk/articles/19002179/dailyupdate?14 http://www.leaddiscovery.co.uk/articles/19002179/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Phase I dose escalation study of telatinib (BAY 57-9352) in patients with advanced solid tumours. http://www.leaddiscovery.co.uk/articles/18992959/dailyupdate?15 http://www.leaddiscovery.co.uk/articles/18992959/dailyupdate Tue, 06 Jan 2009 17:31:06 GMT Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations. http://www.leaddiscovery.co.uk/articles/19010844/dailyupdate?16 http://www.leaddiscovery.co.uk/articles/19010844/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT G-Quadruplex Ligand RHPS4 Potentiates the Antitumor Activity of Camptothecins in Preclinical Models of Solid Tumors. http://www.leaddiscovery.co.uk/articles/18992308/dailyupdate?17 http://www.leaddiscovery.co.uk/articles/18992308/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT In vitro and in vivo evaluation of a paclitaxel conjugate with the divalent peptide E-c(RGDfK)(2) that targets integrin alpha(v)beta(3). http://www.leaddiscovery.co.uk/articles/19010522/dailyupdate?18 http://www.leaddiscovery.co.uk/articles/19010522/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT A phase III study of extended field radiation therapy with concomitant paclitaxel and cisplatin chemotherapy in patients with cervical carcinoma metastatic to the para-aortic lymph nodes: A gynecologic oncology group study. http://www.leaddiscovery.co.uk/articles/19017637/dailyupdate?19 http://www.leaddiscovery.co.uk/articles/19017637/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin - dependent kinase - 4 promoter and inhibiting CDK4 gene expression. http://www.leaddiscovery.co.uk/articles/19010905/dailyupdate?20 http://www.leaddiscovery.co.uk/articles/19010905/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Antitumor effect of SN-38-releasing polymeric micelles NK012 on spontaneous peritoneal metastases from orthotopic gastric cancer in mice compared with irinotecan. http://www.leaddiscovery.co.uk/articles/18951029/dailyupdate?21 http://www.leaddiscovery.co.uk/articles/18951029/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT New retinoid chemotypes: 9 - cis - Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists. http://www.leaddiscovery.co.uk/articles/18993061/dailyupdate?22 http://www.leaddiscovery.co.uk/articles/18993061/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Design and synthesis of a bis(cycloisodityrosine) analogue of RA - VII an antitumor bicyclic hexapeptide. http://www.leaddiscovery.co.uk/articles/19001329/dailyupdate?23 http://www.leaddiscovery.co.uk/articles/19001329/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Association of Serum Interleukin-7 Levels With the Development of Acute Graft-Versus-Host Disease. http://www.leaddiscovery.co.uk/articles/18980550/dailyupdate?24 http://www.leaddiscovery.co.uk/articles/18980550/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Clinical use of anti-epidermal growth factor receptor monoclonal antibodies in metastatic colorectal cancer. http://www.leaddiscovery.co.uk/articles/18996009/dailyupdate?25 http://www.leaddiscovery.co.uk/articles/18996009/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Benzimidazole - and benzoxazole - based inhibitors of Rho kinase. http://www.leaddiscovery.co.uk/articles/19010903/dailyupdate?26 http://www.leaddiscovery.co.uk/articles/19010903/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival. http://www.leaddiscovery.co.uk/articles/19013074/dailyupdate?27 http://www.leaddiscovery.co.uk/articles/19013074/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Studies on quinones. Part 44: Novel angucyclinone N - heterocyclic analogues endowed with antitumoral activity. http://www.leaddiscovery.co.uk/articles/19001146/dailyupdate?28 http://www.leaddiscovery.co.uk/articles/19001146/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Overcoming immunologic tolerance to melanoma: targeting CTLA-4 with tremelimumab (CP-675206). http://www.leaddiscovery.co.uk/articles/19010901/dailyupdate?29 http://www.leaddiscovery.co.uk/articles/19010901/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Targeting HER2-positive breast cancer with trastuzumab-DM1 an antibody-cytotoxic drug conjugate. http://www.leaddiscovery.co.uk/articles/19016067/dailyupdate?30 http://www.leaddiscovery.co.uk/articles/19016067/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Delivery of interleukin-18 gene to lung cancer cells using cationic emulsion. http://www.leaddiscovery.co.uk/articles/19010904/dailyupdate?31 http://www.leaddiscovery.co.uk/articles/19010904/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Human adrenomedullin up-regulates interleukin-13 receptor alpha2 chain in prostate cancer in vitro and in vivo: a novel approach to sensitize prostate cancer to anticancer therapy. http://www.leaddiscovery.co.uk/articles/18980549/dailyupdate?32 http://www.leaddiscovery.co.uk/articles/18980549/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Clinical use of anti-vascular endothelial growth factor monoclonal antibodies in metastatic colorectal cancer. http://www.leaddiscovery.co.uk/articles/18988862/dailyupdate?33 http://www.leaddiscovery.co.uk/articles/18988862/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity. http://www.leaddiscovery.co.uk/articles/19010181/dailyupdate?34 http://www.leaddiscovery.co.uk/articles/19010181/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Adverse effects of Mammalian target of rapamycin inhibitors during the postoperative period after cardiac transplantation. http://www.leaddiscovery.co.uk/articles/19007749/dailyupdate?35 http://www.leaddiscovery.co.uk/articles/19007749/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Inhibition of IL-1beta-mediated inflammatory responses by the IkappaBalpha super-repressor in human fibroblast-like synoviocytes. http://www.leaddiscovery.co.uk/articles/19008341/dailyupdate?36 http://www.leaddiscovery.co.uk/articles/19008341/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Overexpression of SIRT1 protects pancreatic beta-cells against cytokine toxicity through suppressing NF-kappaB signaling pathway. http://www.leaddiscovery.co.uk/articles/19010149/dailyupdate?37 http://www.leaddiscovery.co.uk/articles/19010149/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Treatment with ezetimibe in kidney transplant recipients with uncontrolled dyslipidemia. http://www.leaddiscovery.co.uk/articles/19012178/dailyupdate?38 http://www.leaddiscovery.co.uk/articles/19012178/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT DG-041 inhibits the EP3 prostanoid receptor-A new target for inhibition of platelet function in atherothrombotic disease. http://www.leaddiscovery.co.uk/articles/19011628/dailyupdate?39 http://www.leaddiscovery.co.uk/articles/19011628/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT The histone deacetylase HDAC11 regulates the expression of interleukin 10 and immune tolerance. http://www.leaddiscovery.co.uk/articles/19012363/dailyupdate?40 http://www.leaddiscovery.co.uk/articles/19012363/dailyupdate Tue, 06 Jan 2009 17:31:07 GMT Cost-Effectiveness of Sequential Therapy with Tumor Necrosis Factor Antagonists in Early Rheumatoid Arthritis. http://www.leaddiscovery.co.uk/articles/18985016/dailyupdate?41 http://www.leaddiscovery.co.uk/articles/18985016/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Histone deacetylase inhibitor KBH-A42 inhibits cytokine production in RAW 264.7 macrophage cells and in vivo endotoxemia model. http://www.leaddiscovery.co.uk/articles/18996701/dailyupdate?42 http://www.leaddiscovery.co.uk/articles/18996701/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Novel potent and highly selective human A(3) adenosine receptor antagonists belonging to the 4 - amido - 2 - arylpyrazolo34 - cquinoline series: Molecular docking analysis and pharmacological studies. http://www.leaddiscovery.co.uk/articles/18996597/dailyupdate?43 http://www.leaddiscovery.co.uk/articles/18996597/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Peptides conjugated to gold nanoparticles induce macrophage activation. http://www.leaddiscovery.co.uk/articles/19010295/dailyupdate?44 http://www.leaddiscovery.co.uk/articles/19010295/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Efficacy of tetrathiomolybdate in a mouse model of multiple sclerosis. http://www.leaddiscovery.co.uk/articles/19008007/dailyupdate?45 http://www.leaddiscovery.co.uk/articles/19008007/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Rosiglitazone preserves islet beta-cell function of adult-onset latent autoimmune diabetes in 3 years follow-up study. http://www.leaddiscovery.co.uk/articles/18989147/dailyupdate?46 http://www.leaddiscovery.co.uk/articles/18989147/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Adefovir combined with hepatitis C virus treatment may prevent hepatitis B reactivation after hepatitis C virus eradication in hepatitis B and C virus carriers. http://www.leaddiscovery.co.uk/articles/18986246/dailyupdate?47 http://www.leaddiscovery.co.uk/articles/18986246/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Two-Months-off Four-Months-on Antiretroviral Regimen Increases the Risk of Resistance Compared with Continuous Therapy: A Randomized Trial Involving West African Adults. http://www.leaddiscovery.co.uk/articles/19005489/dailyupdate?48 http://www.leaddiscovery.co.uk/articles/19005489/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT High-Level Expression of Glycoprotein D by a Dominant-Negative HSV-1 Virus Augments its Efficacy as a Vaccine against HSV-1 Infection. http://www.leaddiscovery.co.uk/articles/18987137/dailyupdate?49 http://www.leaddiscovery.co.uk/articles/18987137/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT The Viral Inhibitor of Apoptosis vFLIPK13 Protects Endothelial Cells against Superoxide-induced Cell Death. http://www.leaddiscovery.co.uk/articles/19015343/dailyupdate?50 http://www.leaddiscovery.co.uk/articles/19015343/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT THE MULTIPLE-DOSE PHARMACOKINETIC BEHAVIOUR OF ELVUCITABINE A NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR WHEN ADMINISTERED OVER 21 DAYS WITH LOPINAVIRRITONAVIR IN HIV-1 SUBJECTS. http://www.leaddiscovery.co.uk/articles/19012954/dailyupdate?51 http://www.leaddiscovery.co.uk/articles/19012954/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind randomised placebo-controlled test-of-concept trial. http://www.leaddiscovery.co.uk/articles/19010669/dailyupdate?52 http://www.leaddiscovery.co.uk/articles/19010669/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Synthesis and antifungal activity of 1H - pyrrolo32 - gquinoline - 49 - diones and 49 - dioxo - 49 - dihydro - 1H - benzofindoles. http://www.leaddiscovery.co.uk/articles/19015327/dailyupdate?53 http://www.leaddiscovery.co.uk/articles/19015327/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Activity of the oral neuraminidase inhibitor A-322278 against the oseltamivir-resistant H274Y (AH1N1) influenza mutant in mice. http://www.leaddiscovery.co.uk/articles/19002647/dailyupdate?54 http://www.leaddiscovery.co.uk/articles/19002647/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT A DNA vaccine candidate expressing dengue-3 virus prM and E proteins elicits neutralizing antibodies and protects mice against lethal challenge. http://www.leaddiscovery.co.uk/articles/18996892/dailyupdate?55 http://www.leaddiscovery.co.uk/articles/18996892/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT INTERFEROME: the database of interferon regulated genes. http://www.leaddiscovery.co.uk/articles/19001626/dailyupdate?56 http://www.leaddiscovery.co.uk/articles/19001626/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Extensively drug-resistant tuberculosis in the United States 1993-2007. http://www.leaddiscovery.co.uk/articles/19017445/dailyupdate?57 http://www.leaddiscovery.co.uk/articles/19017445/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Consensus statement on the revised World Health Organization recommendations for BCG vaccination in HIV-infected infants: Submitted on behalf of the BCG Working Group Child Lung Health Section International Union Against Tuberculosis and Lung Disease 38th Union World Conference on Lung Health Cape Town 8-12 November 2007. http://www.leaddiscovery.co.uk/articles/19014951/dailyupdate?58 http://www.leaddiscovery.co.uk/articles/19014951/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Defining the DNA Substrate Binding Sites on HIV-1 Integrase. http://www.leaddiscovery.co.uk/articles/18996017/dailyupdate?59 http://www.leaddiscovery.co.uk/articles/18996017/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Convergent synthesis and cruzain inhibitory activity of novel 2 - (N - benzylidenehydrazino) - 4 - trifluoromethyl - pyrimidines. http://www.leaddiscovery.co.uk/articles/18989234/dailyupdate?60 http://www.leaddiscovery.co.uk/articles/18989234/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Efavirenz Induces CYP2B6-Mediated Hydroxylation of Bupropion in Healthy Subjects. http://www.leaddiscovery.co.uk/articles/19011440/dailyupdate?61 http://www.leaddiscovery.co.uk/articles/19011440/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Influence of olanzapine on QT variability and complexity measures of heart rate in patients with schizophrenia. http://www.leaddiscovery.co.uk/articles/19006260/dailyupdate?62 http://www.leaddiscovery.co.uk/articles/19006260/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Escitalopram in the treatment of major depressive disorder in primary-care settings: an open-label trial. http://www.leaddiscovery.co.uk/articles/19000709/dailyupdate?63 http://www.leaddiscovery.co.uk/articles/19000709/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Nicotine metabolic rate predicts successful smoking cessation with transdermal nicotine: A validation study. http://www.leaddiscovery.co.uk/articles/19015230/dailyupdate?64 http://www.leaddiscovery.co.uk/articles/19015230/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT A Meta-Analysis of Head-to-Head Comparisons of Second-Generation Antipsychotics in the Treatment of Schizophrenia. http://www.leaddiscovery.co.uk/articles/18989952/dailyupdate?65 http://www.leaddiscovery.co.uk/articles/18989952/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Synthesis and Pharmacological Characterization of Novel Druglike Corticotropin - Releasing Factor 1 Antagonists. http://www.leaddiscovery.co.uk/articles/19010741/dailyupdate?66 http://www.leaddiscovery.co.uk/articles/19010741/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Preoperative Anxiolytic Effect of Melatonin and Clonidine on Postoperative Pain and Morphine Consumption in Patients Undergoing Abdominal Hysterectomy: A Double-Blind Randomized Placebo-Controlled Study. http://www.leaddiscovery.co.uk/articles/19013203/dailyupdate?67 http://www.leaddiscovery.co.uk/articles/19013203/dailyupdate Tue, 06 Jan 2009 17:31:08 GMT Liposome encapsulated polyethylenimineODN polyplexes for brain targeting. http://www.leaddiscovery.co.uk/articles/19005077/dailyupdate?68 http://www.leaddiscovery.co.uk/articles/19005077/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Crucial role of CB(2) cannabinoid receptor in the regulation of central immune responses during neuropathic pain. http://www.leaddiscovery.co.uk/articles/19005078/dailyupdate?69 http://www.leaddiscovery.co.uk/articles/19005078/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Interferon-gamma is a critical modulator of CB(2) cannabinoid receptor signaling during neuropathic pain. http://www.leaddiscovery.co.uk/articles/19010671/dailyupdate?70 http://www.leaddiscovery.co.uk/articles/19010671/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Pyridine - 3 - carboxamides as novel CB(2) agonists for analgesia. http://www.leaddiscovery.co.uk/articles/19006672/dailyupdate?71 http://www.leaddiscovery.co.uk/articles/19006672/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Polyethylene glycol - based homologated ligands for nicotinic acetylcholine receptors. http://www.leaddiscovery.co.uk/articles/18996482/dailyupdate?72 http://www.leaddiscovery.co.uk/articles/18996482/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT The co-inhibitory molecule PD-1 modulates disease severity in a model for an inherited demyelinating neuropathy. http://www.leaddiscovery.co.uk/articles/18993000/dailyupdate?73 http://www.leaddiscovery.co.uk/articles/18993000/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Effect of topiramate in combination with lidocaine and phenobarbital in acute encephalitis with refractory repetitive partial seizures. http://www.leaddiscovery.co.uk/articles/19005060/dailyupdate?74 http://www.leaddiscovery.co.uk/articles/19005060/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity. http://www.leaddiscovery.co.uk/articles/18989258/dailyupdate?75 http://www.leaddiscovery.co.uk/articles/18989258/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Effects of Telmisartan and Ramipril on Adiponectin and Blood Pressure in Patients with Type 2 Diabetes. http://www.leaddiscovery.co.uk/articles/19015648/dailyupdate?76 http://www.leaddiscovery.co.uk/articles/19015648/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Pregabalin for painful diabetic peripheral neuropathy. http://www.leaddiscovery.co.uk/articles/18993152/dailyupdate?77 http://www.leaddiscovery.co.uk/articles/18993152/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Comparison of treatment of severe high-density lipoprotein cholesterol deficiency in men with daily atorvastatin (20 mg) versus fenofibrate (200 mg) versus extended-release niacin (2 g). http://www.leaddiscovery.co.uk/articles/19008530/dailyupdate?78 http://www.leaddiscovery.co.uk/articles/19008530/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Soluble N-Cadherin Overexpression Reduces Features of Atherosclerotic Plaque Instability. http://www.leaddiscovery.co.uk/articles/18990567/dailyupdate?79 http://www.leaddiscovery.co.uk/articles/18990567/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Rational design of novel glycomimetics: Inhibitors of concanavalin A. http://www.leaddiscovery.co.uk/articles/19013295/dailyupdate?80 http://www.leaddiscovery.co.uk/articles/19013295/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia. http://www.leaddiscovery.co.uk/articles/18988128/dailyupdate?81 http://www.leaddiscovery.co.uk/articles/18988128/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT ZT-031 a cyclized analog of parathyroid hormone(1-31) for the potential treatment of osteoporosis. http://www.leaddiscovery.co.uk/articles/18993150/dailyupdate?82 http://www.leaddiscovery.co.uk/articles/18993150/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Meta-analysis comparison (nine trials) of outcomes with drug-eluting stents versus bare metal stents in patients with diabetes mellitus. http://www.leaddiscovery.co.uk/articles/19015590/dailyupdate?83 http://www.leaddiscovery.co.uk/articles/19015590/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT The Short Treatment with the Angiotensin Receptor Blocker Candesartan Surveyed by Telemedicine (STAR CAST) Study: Rationale and Study Design. http://www.leaddiscovery.co.uk/articles/19010810/dailyupdate?84 http://www.leaddiscovery.co.uk/articles/19010810/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Rosiglitazone Inhibits Hypercholesterolemia-Induced Myeloperoxidase Upregulation -a Novel Mechanism for the Cardioprotective Effects of PPAR Agonists. http://www.leaddiscovery.co.uk/articles/19013076/dailyupdate?85 http://www.leaddiscovery.co.uk/articles/19013076/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Structure - activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase - 1: Alkenyl - amidines as new leads. http://www.leaddiscovery.co.uk/articles/19007316/dailyupdate?86 http://www.leaddiscovery.co.uk/articles/19007316/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT A novel IKK inhibitor suppresses heart failure and chronic remodeling after myocardial ischemia via MMP alteration. http://www.leaddiscovery.co.uk/articles/19011773/dailyupdate?87 http://www.leaddiscovery.co.uk/articles/19011773/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Landiolol has a less potent negative inotropic effect than esmolol in isolated rabbit hearts. http://www.leaddiscovery.co.uk/articles/18987674/dailyupdate?88 http://www.leaddiscovery.co.uk/articles/18987674/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT A cell penetrating heme oxygenase protein protects heart graft against ischemiareperfusion injury. http://www.leaddiscovery.co.uk/articles/18993148/dailyupdate?89 http://www.leaddiscovery.co.uk/articles/18993148/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Impact of a 600-mg loading dose of clopidogrel on 30-day outcome in unselected patients undergoing percutaneous coronary intervention. http://www.leaddiscovery.co.uk/articles/19006286/dailyupdate?90 http://www.leaddiscovery.co.uk/articles/19006286/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Discovery of Sodium R - () - 4 - 2 - 5 - (2 - Fluoro - 3 - methoxyphenyl) - 3 - (2 - fluoro - 6 - trifluoromethylbenzyl) - 4 - methyl - 26 - dioxo - 36 - dihydro - 2H - pyrimidin - 1 - yl - 1 - phenylethylaminobutyrate (Elagolix) a Potent and Orally Available Nonpeptide Antagonist of the Human Gonadotropin - Releasing Hormone Receptor. http://www.leaddiscovery.co.uk/articles/19010489/dailyupdate?91 http://www.leaddiscovery.co.uk/articles/19010489/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT GRC-6211 A New Oral Specific TRPV1 Antagonist Decreases Bladder Overactivity and Noxious Bladder Input in Cystitis Animal Models. http://www.leaddiscovery.co.uk/articles/18990175/dailyupdate?92 http://www.leaddiscovery.co.uk/articles/18990175/dailyupdate Tue, 06 Jan 2009 17:31:09 GMT Solifenacin in the treatment of urgency and other symptoms of overactive bladder: results from a randomized double-blind placebo-controlled rising-dose trial. http://www.leaddiscovery.co.uk/articles/19010868/dailyupdate?93 http://www.leaddiscovery.co.uk/articles/19010868/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT Vaccination of Renal Cell Cancer Patients with Modified Vaccinia Ankara Delivering Tumor Antigen 5T4 (TroVax) Administered with Interleukin 2: A Phase II Trial. http://www.leaddiscovery.co.uk/articles/19017527/dailyupdate?94 http://www.leaddiscovery.co.uk/articles/19017527/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT Hepatic siRNA delivery using recombinant human apolipoprotein A-I in mice. http://www.leaddiscovery.co.uk/articles/19010240/dailyupdate?95 http://www.leaddiscovery.co.uk/articles/19010240/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT Alemtuzumab induction in kidney transplantation: clinical results and impact on T-regulatory cells. http://www.leaddiscovery.co.uk/articles/18987103/dailyupdate?96 http://www.leaddiscovery.co.uk/articles/18987103/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT The results of two multicenter open-label studies assessing efficacy tolerability and safety of protiramer a high molecular weight synthetic copolymeric mixture in patients with relapsing-remitting multiple sclerosis. http://www.leaddiscovery.co.uk/articles/18985779/dailyupdate?97 http://www.leaddiscovery.co.uk/articles/18985779/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT In vivo analysis of biocompatibility and vascularization of the synthetic bone grafting substitute NanoBone(R). http://www.leaddiscovery.co.uk/articles/18987590/dailyupdate?98 http://www.leaddiscovery.co.uk/articles/18987590/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT New performance of biosensor technology for Alzheimers disease drugs: in vitro comparison of tacrine and 7-methoxytacrine. http://www.leaddiscovery.co.uk/articles/18983828/dailyupdate?99 http://www.leaddiscovery.co.uk/articles/18983828/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT RLIP76: A novel glutathione-conjugate and multi-drug transporter. http://www.leaddiscovery.co.uk/articles/19010154/dailyupdate?100 http://www.leaddiscovery.co.uk/articles/19010154/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT Response to a Vaccination Schedule With 4 Doses of 40 mug Against Hepatitis B Virus in Cirrhotic Patients Evaluated for Liver Transplantation. http://www.leaddiscovery.co.uk/articles/19012957/dailyupdate?101 http://www.leaddiscovery.co.uk/articles/19012957/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis. http://www.leaddiscovery.co.uk/articles/19010859/dailyupdate?102 http://www.leaddiscovery.co.uk/articles/19010859/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT 18FFluorothymidine Positron Emission Tomography before and 7 Days after Gefitinib Treatment Predicts Response in Patients with Advanced Adenocarcinoma of the Lung. http://www.leaddiscovery.co.uk/articles/19010858/dailyupdate?103 http://www.leaddiscovery.co.uk/articles/19010858/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT Molecular Imaging of Therapeutic Response to Epidermal Growth Factor Receptor Blockade in Colorectal Cancer. http://www.leaddiscovery.co.uk/articles/19016323/dailyupdate?104 http://www.leaddiscovery.co.uk/articles/19016323/dailyupdate Tue, 06 Jan 2009 17:31:10 GMT Detection of occult HER2 mRNA-positive tumor cells in the peripheral blood of patients with operable breast cancer: evaluation of their prognostic relevance. http://www.leaddiscovery.co.uk/news/4094?105 http://www.leaddiscovery.co.uk/news/4094 Tue, 06 Jan 2009 17:31:11 GMT YM BIOSCIENCES RECEIVES CLEARANCE TO INITIATE RANDOMIZED DOUBLE-BLIND CLINICAL TRIALS OF NIMOTUZUMAB IN LUNG CANCER AND BRAIN METASTASES FROM LUNG CANCER http://www.leaddiscovery.co.uk/news/4093?106 http://www.leaddiscovery.co.uk/news/4093 Tue, 06 Jan 2009 17:31:11 GMT Prism Pharmaceuticals Receives FDA Approval of NEXTERONE for Life-Threatening Ventricular Fibrillation and Ventricular Tachycardia http://www.leaddiscovery.co.uk/news/4095?107 http://www.leaddiscovery.co.uk/news/4095 Tue, 06 Jan 2009 17:31:11 GMT Phase III Studies of EXPAREL (DepoBupivacaine) from Pacira Complete Enrollment http://www.leaddiscovery.co.uk/news/4096?108 http://www.leaddiscovery.co.uk/news/4096 Tue, 06 Jan 2009 17:31:11 GMT Immutep Announces Positive Interim Results in Phase III Chemoimmunotherapy Trial in Breast Cancer. http://www.leaddiscovery.co.uk/news/4097?109 http://www.leaddiscovery.co.uk/news/4097 Tue, 06 Jan 2009 17:31:11 GMT KYTHERA BIOPHARMACEUTICALS ANNOUNCES POSITIVE RESULTS FROM TWO PHASE 2 STUDIES WITH ATX-101 DEMONSTRATING REDUCTION OF SUBMENTAL FAT http://www.leaddiscovery.co.uk/news/4098?110 http://www.leaddiscovery.co.uk/news/4098 Tue, 06 Jan 2009 17:31:11 GMT Medtronic Announces Clinical Trial of Stent for Peripheral Arterial Disease http://www.leaddiscovery.co.uk/news/4099?111 http://www.leaddiscovery.co.uk/news/4099 Tue, 06 Jan 2009 17:31:11 GMT DOR BioPharma Receives SPA Clearance from the FDA to Begin Confirmatory Phase 3 Clinical Trial of orBec in GI GVHD http://www.leaddiscovery.co.uk/news/4100?112 http://www.leaddiscovery.co.uk/news/4100 Tue, 06 Jan 2009 17:31:11 GMT GENMAB ANNOUNCES INTERIM RESULTS IN PIVOTAL STUDY OF ZALUTUMUMAB IN HEAD AND NECK CANCER http://www.leaddiscovery.co.uk/news/4101?113 http://www.leaddiscovery.co.uk/news/4101 Tue, 06 Jan 2009 17:31:11 GMT Genta Summarizes Phase 2 Activity and Receives Orphan Drug Designation in Gastric Cancer for Tesetaxel a Leading Oral Taxane in Clinical Development http://www.leaddiscovery.co.uk/news/4102?114 http://www.leaddiscovery.co.uk/news/4102 Tue, 06 Jan 2009 17:31:11 GMT Cylene Pharmaceuticals Initiates Phase I Trial with CX-4945 Breakthrough First-in Class Inhibitor of CK2 http://www.leaddiscovery.co.uk/news/4103?115 http://www.leaddiscovery.co.uk/news/4103 Tue, 06 Jan 2009 17:31:11 GMT Chimerix completes Phase I study and initiates a Phase II multi-dose clinical trial for CMX001 http://www.leaddiscovery.co.uk/trials/3925?116 http://www.leaddiscovery.co.uk/trials/3925 Tue, 06 Jan 2009 17:31:11 GMT Study of CarboplatinPaclitaxel in Combination With ABT-869 in Subjects With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) http://www.leaddiscovery.co.uk/trials/3927?117 http://www.leaddiscovery.co.uk/trials/3927 Tue, 06 Jan 2009 17:31:11 GMT Study of the Safety and Pharmacokinetics of Carfilzomib in Subjects With Relapsed and Refractory Multiple Myeloma and Varying Degrees of Renal Function http://www.leaddiscovery.co.uk/trials/3932?118 http://www.leaddiscovery.co.uk/trials/3932 Tue, 06 Jan 2009 17:31:11 GMT A Phase I Study of SB1518 for the Treatment of Advanced Myeloid Malignancies http://www.leaddiscovery.co.uk/trials/5174?119 http://www.leaddiscovery.co.uk/trials/5174 Tue, 06 Jan 2009 17:31:11 GMT A Dose Escalation Study to Evaluate the Safety Tolerability and Antitumor Activity of MEDI-575 in Subjects With Advanced Tumors. http://www.leaddiscovery.co.uk/trials/5181?120 http://www.leaddiscovery.co.uk/trials/5181 Tue, 06 Jan 2009 17:31:11 GMT Immunologic Diagnostic Blood Test in Predicting Side-Effects in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer or Other Diseases http://www.leaddiscovery.co.uk/trials/5182?121 http://www.leaddiscovery.co.uk/trials/5182 Tue, 06 Jan 2009 17:31:11 GMT A Study of Avastin (Bevacizumab) in Patients With Non-Squamous Non-Small Cell Lung Cancer With Asymptomatic Untreated Brain Metastasis http://www.leaddiscovery.co.uk/trials/5175?122 http://www.leaddiscovery.co.uk/trials/5175 Tue, 06 Jan 2009 17:31:11 GMT Effects of the Ivabradine on Reduction of Inflammatory Markers in Patients With Acute Coronary Syndrome http://www.leaddiscovery.co.uk/trials/5186?123 http://www.leaddiscovery.co.uk/trials/5186 Tue, 06 Jan 2009 17:31:11 GMT Efficacy Safety and Tolerability of Nerispirdine in Patients With Multiple Sclerosis http://www.leaddiscovery.co.uk/trials/5201?124 http://www.leaddiscovery.co.uk/trials/5201 Tue, 06 Jan 2009 17:31:11 GMT Study Evaluating Single Doses of SBI-087 in Japanese Subjects With Rheumatoid Arthritis http://www.leaddiscovery.co.uk/trials/5180?125 http://www.leaddiscovery.co.uk/trials/5180 Tue, 06 Jan 2009 17:31:11 GMT Double-Blind Dose-Escalation Study of IDX184 in Chronic Hepatitis C Treatment-Nave Subjects http://www.leaddiscovery.co.uk/trials/5183?126 http://www.leaddiscovery.co.uk/trials/5183 Tue, 06 Jan 2009 17:31:11 GMT Efavirenz in HIV-Infected and HIVTB Co-Infected Children http://www.leaddiscovery.co.uk/trials/5185?127 http://www.leaddiscovery.co.uk/trials/5185 Tue, 06 Jan 2009 17:31:11 GMT Efficacy of Treatment Intensification With Maraviroc on HIV-1 Viral Latency in Recently Infected Hiv-1 nave Patients Starting Raltegravir Plus TenofovirEmtricitabine http://www.leaddiscovery.co.uk/trials/5171?128 http://www.leaddiscovery.co.uk/trials/5171 Tue, 06 Jan 2009 17:31:11 GMT Comparison of Optimal Antipsychotic Treatments for Adults With Schizophrenia http://www.leaddiscovery.co.uk/trials/5173?129 http://www.leaddiscovery.co.uk/trials/5173 Tue, 06 Jan 2009 17:31:11 GMT Varenicline in Bipolar Depressed Patients http://www.leaddiscovery.co.uk/trials/5203?130 http://www.leaddiscovery.co.uk/trials/5203 Tue, 06 Jan 2009 17:31:11 GMT Study Evaluating Desvenlafaxine Succinate Sustained Release (DVS SR) in the Treatment of Major Depressive Disorder http://www.leaddiscovery.co.uk/trials/5199?131 http://www.leaddiscovery.co.uk/trials/5199 Tue, 06 Jan 2009 17:31:11 GMT Evaluate the Onset of Action of SKY0402 Following Local Infiltration in Healthy Volunteers (TTO) http://www.leaddiscovery.co.uk/trials/5200?132 http://www.leaddiscovery.co.uk/trials/5200 Tue, 06 Jan 2009 17:31:11 GMT A Study of Rizatriptan for the Treatment of Acute Migraine in Patients on Topiramate for Migraine Prophylaxis http://www.leaddiscovery.co.uk/trials/5242?133 http://www.leaddiscovery.co.uk/trials/5242 Tue, 06 Jan 2009 17:31:11 GMT Oral Civamide Safety Tolerability First in Human Study http://www.leaddiscovery.co.uk/trials/5176?134 http://www.leaddiscovery.co.uk/trials/5176 Tue, 06 Jan 2009 17:31:11 GMT A Safety and Tolerability Study of Intracerebroventricular Administration of sNN0029 to Patients With Amyotrophic Lateral Sclerosis http://www.leaddiscovery.co.uk/trials/5184?135 http://www.leaddiscovery.co.uk/trials/5184 Tue, 06 Jan 2009 17:31:11 GMT Efficacy and Safety Study of Aplindore in Patients With Early Parkinson Disease http://www.leaddiscovery.co.uk/trials/5170?136 http://www.leaddiscovery.co.uk/trials/5170 Tue, 06 Jan 2009 17:31:11 GMT Effects of Rosuvastatin on Aortic Stenosis Progression (ASTRONOMER) http://www.leaddiscovery.co.uk/trials/5190?137 http://www.leaddiscovery.co.uk/trials/5190 Tue, 06 Jan 2009 17:31:11 GMT Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-Lowering Ezetimibe and the Non-Nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4 UGT1A1 ABCB1 and ABCC2 http://www.leaddiscovery.co.uk/trials/5191?138 http://www.leaddiscovery.co.uk/trials/5191 Tue, 06 Jan 2009 17:31:11 GMT The Stabilization of Atherosclerotic Plaque by Initiation of Darapladib Therapy Trial (STABILITY) http://www.leaddiscovery.co.uk/trials/5179?139 http://www.leaddiscovery.co.uk/trials/5179 Tue, 06 Jan 2009 17:31:11 GMT Efficacy and Safety Study of BERIPLEX PN Compared With Plasma in Patients on Anticoagulant Therapy Who Require Emergency Surgery or Invasive Intervention http://www.leaddiscovery.co.uk/trials/5248?140 http://www.leaddiscovery.co.uk/trials/5248 Tue, 06 Jan 2009 17:31:11 GMT A Study to Investigate How the Body Handles Multiple Doses of PF-0243873 and to Investigate the Effect of PF-02413873 on Sex Hormone Levels in Healthy Young Women http://www.leaddiscovery.co.uk/trials/5189?141 http://www.leaddiscovery.co.uk/trials/5189 Tue, 06 Jan 2009 17:31:11 GMT Pemetrexed Carboplatin and Bevacizumab as First-Line Therapy in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer http://www.leaddiscovery.co.uk/trials/5172?142 http://www.leaddiscovery.co.uk/trials/5172 Tue, 06 Jan 2009 17:31:11 GMT Efficacy of CT-Guided Brachytherapy Versus Transarterial Chemoembolization in Patients With Unresectable Hepatocellular Carcinoma (HCC) (AL vs TACE) http://www.leaddiscovery.co.uk/trials/5196?143 http://www.leaddiscovery.co.uk/trials/5196 Tue, 06 Jan 2009 17:31:11 GMT Phase 2 Safety Efficacy of FOLFIRI in Combination With AMG 479 or AMG 655 vs FOLFIRI in KRAS-Mutant Metastatic Colorectal Carcinoma http://www.leaddiscovery.co.uk/reports/170?144 http://www.leaddiscovery.co.uk/reports/170 Tue, 06 Jan 2009 17:31:11 GMT Animal Biotechnology - Technologies Markets and Companies http://www.leaddiscovery.co.uk/reports/171?145 http://www.leaddiscovery.co.uk/reports/171 Tue, 06 Jan 2009 17:31:11 GMT Pain Therapeutics - Drugs Markets and Companies http://www.leaddiscovery.co.uk/reports/172?146 http://www.leaddiscovery.co.uk/reports/172 Tue, 06 Jan 2009 17:31:11 GMT Personalized Medicine - scientific and commercial aspects http://www.leaddiscovery.co.uk/reports/173?147 http://www.leaddiscovery.co.uk/reports/173 Tue, 06 Jan 2009 17:31:11 GMT Nitric Oxide - Therapeutics Markets and Companies http://www.leaddiscovery.co.uk/reports/174?148 http://www.leaddiscovery.co.uk/reports/174 Tue, 06 Jan 2009 17:31:11 GMT Alzheimer disease - new drugs markets and companies