DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery http://www.leaddiscovery.co.uk Dedicated to drug discovery, LeadDiscovery was founded in 1998 by life scientists for life scientists. Thu, 11 Mar 2010 21:19:54 GMT DailyUpdates http://www.leaddiscovery.co.uk Breaking Research, Development News and Pharmareports for Drug Discovery http://www.leaddiscovery.co.uk/dailyupdates_RSS_Icon.gif 144 59 http://www.leaddiscovery.co.uk/articles/20156909/dailyupdate?1 http://www.leaddiscovery.co.uk/articles/20156909/dailyupdate Thu, 11 Mar 2010 21:19:49 GMT Randomized Phase III Clinical Trial of Five Different Arms of Treatment in 332 Patients with Cancer Cachexia. http://www.leaddiscovery.co.uk/articles/20066470/dailyupdate?2 http://www.leaddiscovery.co.uk/articles/20066470/dailyupdate Thu, 11 Mar 2010 21:19:49 GMT Antiproliferative activity mechanism of action and oral antitumor activity of CP-4126 a fatty acid derivative of gemcitabine in in vitro and in vivo tumor models. http://www.leaddiscovery.co.uk/articles/20154064/dailyupdate?3 http://www.leaddiscovery.co.uk/articles/20154064/dailyupdate Thu, 11 Mar 2010 21:19:49 GMT HEAT SHOCK PROTEIN 90 INHIBITORS ATTENUATE INFLAMMATORY RESPONSES IN ATHEROSCLEROSIS. http://www.leaddiscovery.co.uk/articles/20146482/dailyupdate?4 http://www.leaddiscovery.co.uk/articles/20146482/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Discovery of 4 - (4 - (2 - ((5 - Hydroxy - 1234 - tetrahydronaphthalen - 2 - yl)(propyl)amino)ethyl)piperazin - 1 - yl)quinolin - 8 - ol and Its Analogues as Highly Potent Dopamine D2D3 Agonists and as Iron Chelator: In Vivo Activity Indicates Potential Application in Symptomatic and Neuroprotective Therapy for Parkinsons Disease. http://www.leaddiscovery.co.uk/articles/20156674/dailyupdate?5 http://www.leaddiscovery.co.uk/articles/20156674/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Treating triple-negative breast cancer by a combination of rapamycin and cyclophosphamide: An in vivo bioluminescence imaging study. http://www.leaddiscovery.co.uk/articles/20150764/dailyupdate?6 http://www.leaddiscovery.co.uk/articles/20150764/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells. http://www.leaddiscovery.co.uk/articles/20151971/dailyupdate?7 http://www.leaddiscovery.co.uk/articles/20151971/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT A placebo-controlled exploratory study investigating the efficacy and safety of the phosphodiesterase type 5 inhibitor UK-369003 for the treatment of men with storage lower urinary tract symptoms associated with a clinical diagnosis of overactive bladder. http://www.leaddiscovery.co.uk/articles/20151997/dailyupdate?8 http://www.leaddiscovery.co.uk/articles/20151997/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Ezetimibe added to atorvastatin compared with doubling the atorvastatin dose in patients at high risk for coronary heart disease with diabetes mellitus metabolic syndrome or neither. http://www.leaddiscovery.co.uk/articles/20155988/dailyupdate?9 http://www.leaddiscovery.co.uk/articles/20155988/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Efficacy and Safety of Ezetimibe for Japanese Patients with Dyslipidaemia: The ESSENTIAL Study. http://www.leaddiscovery.co.uk/articles/20156949/dailyupdate?10 http://www.leaddiscovery.co.uk/articles/20156949/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT A European Multicenter Randomized Double-blind Placebo-controlled Monotherapy Clinical Trial of Milnacipran in the Treatment of Fibromyalgia. http://www.leaddiscovery.co.uk/articles/20153647/dailyupdate?11 http://www.leaddiscovery.co.uk/articles/20153647/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT The identification of a selective dopamine D(2) partial agonist D(3) antagonist displaying high levels of brain exposure. http://www.leaddiscovery.co.uk/articles/20156099/dailyupdate?12 http://www.leaddiscovery.co.uk/articles/20156099/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Differential Effects of P-Class Versus Other CpG Oligodeoxynucleotide Classes on the Impaired Innate Immunity of Plasmacytoid Dendritic Cells in HIV Type 1 Infection. http://www.leaddiscovery.co.uk/articles/20146556/dailyupdate?13 http://www.leaddiscovery.co.uk/articles/20146556/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Pharmacokinetics and disposition of CS-8958 a long-acting prodrug of the novel neuraminidase inhibitor laninamivir in rats. http://www.leaddiscovery.co.uk/articles/20149495/dailyupdate?14 http://www.leaddiscovery.co.uk/articles/20149495/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Synthesis and antiviral activity of new acrylamide derivatives containing 123 - thiadiazole as inhibitors of hepatitis B virus replication. http://www.leaddiscovery.co.uk/articles/20156156/dailyupdate?15 http://www.leaddiscovery.co.uk/articles/20156156/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Clinical Pharmacology and Lesion Penetrating Properties of Second- and Third-Line Antituberculous Agents used in the Management of Multidrug-Resistant (MDR) and Extensively-Drug Resistant (XDR) Tuberculosis. http://www.leaddiscovery.co.uk/articles/20150524/dailyupdate?16 http://www.leaddiscovery.co.uk/articles/20150524/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Population Pharmacokinetics and Pharmacodynamics of Inhaled Ciclesonide and Fluticasone Propionate in Patients With Persistent Asthma. http://www.leaddiscovery.co.uk/articles/20156700/dailyupdate?17 http://www.leaddiscovery.co.uk/articles/20156700/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Tapered dose versus constant drug exposure to anti-EGFR drugs on head-and-neck cancer xenografts. A comparison between cetuximab and gefitinib. http://www.leaddiscovery.co.uk/articles/20155316/dailyupdate?18 http://www.leaddiscovery.co.uk/articles/20155316/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Influence of the phosphodiesterase-5 inhibitor sildenafil on sensitivity to chemotherapy in breast tumor cells. http://www.leaddiscovery.co.uk/articles/20151671/dailyupdate?19 http://www.leaddiscovery.co.uk/articles/20151671/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Small Molecule Inhibitors of the Neuropilin - 1 Vascular Endothelial Growth Factor A (VEGF - A) Interaction. http://www.leaddiscovery.co.uk/articles/20148562/dailyupdate?20 http://www.leaddiscovery.co.uk/articles/20148562/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT 5 - Amino - 2 - Aroylquinolines as Highly Potent Tubulin Polymerization Inhibitors. http://www.leaddiscovery.co.uk/articles/20149664/dailyupdate?21 http://www.leaddiscovery.co.uk/articles/20149664/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Synthesis in vitro progesterone receptors affinity of gadolinium containing mifepristone conjugates and estimation of binding sites in human breast cancer cells. http://www.leaddiscovery.co.uk/articles/20150589/dailyupdate?22 http://www.leaddiscovery.co.uk/articles/20150589/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Multidrug Resistance Reversal Agent NSC77037 Identified with a Cell-Based Screening Assay. http://www.leaddiscovery.co.uk/articles/20153187/dailyupdate?23 http://www.leaddiscovery.co.uk/articles/20153187/dailyupdate Thu, 11 Mar 2010 21:19:50 GMT Dioxo - triazines as a novel series of cathepsin K inhibitors. http://www.leaddiscovery.co.uk/news/6520?24 http://www.leaddiscovery.co.uk/news/6520 Thu, 11 Mar 2010 21:19:52 GMT Evotec Reports Good Progress in Product Development in Treatment-Resistant Depression in its Alliance with Roche http://www.leaddiscovery.co.uk/news/6519?25 http://www.leaddiscovery.co.uk/news/6519 Thu, 11 Mar 2010 21:19:52 GMT Request for re-examination of ceftobiprole submitted to CHMP http://www.leaddiscovery.co.uk/news/6521?26 http://www.leaddiscovery.co.uk/news/6521 Thu, 11 Mar 2010 21:19:52 GMT FDA Approves Boston Scientifics Express LD Iliac Stent System http://www.leaddiscovery.co.uk/news/6522?27 http://www.leaddiscovery.co.uk/news/6522 Thu, 11 Mar 2010 21:19:52 GMT FDA Grants Orphan Drug Status to Ciprofloxacin Dry Powder Inhaler for the Treatment of Cystic Fibrosis http://www.leaddiscovery.co.uk/news/6523?28 http://www.leaddiscovery.co.uk/news/6523 Thu, 11 Mar 2010 21:19:52 GMT Dainippon Sumitomo Pharma America Announces FDA Acceptance of Lurasidone New Drug Application for Treatment of Schizophrenia http://www.leaddiscovery.co.uk/news/6524?29 http://www.leaddiscovery.co.uk/news/6524 Thu, 11 Mar 2010 21:19:52 GMT ADVAXIS DEVELOPS ROOM TEMPERATURE FORMULATION OF ADXS11-001 http://www.leaddiscovery.co.uk/news/6525?30 http://www.leaddiscovery.co.uk/news/6525 Thu, 11 Mar 2010 21:19:52 GMT Allons Phase 1 trial broadens davunetides intranasal safety and dose range http://www.leaddiscovery.co.uk/trials/7893?31 http://www.leaddiscovery.co.uk/trials/7893 Thu, 11 Mar 2010 21:19:52 GMT TRANSIT - A Safety and Efficacy Study of Ustekinumab in Patients With Plaque Psoriasis Who Have Had an Inadequate Response to Methotrexate http://www.leaddiscovery.co.uk/trials/7890?32 http://www.leaddiscovery.co.uk/trials/7890 Thu, 11 Mar 2010 21:19:52 GMT Simvastatin Therapy for Moderate and Severe COPD (STATCOPE) http://www.leaddiscovery.co.uk/trials/7885?33 http://www.leaddiscovery.co.uk/trials/7885 Thu, 11 Mar 2010 21:19:52 GMT Effect on Structural Changes in Airways Measured by MSCT of Twice Daily 60mg AZD9668 for 12 Weeks in Chronic Obstructive Pulmonary Disease (COPD) Patients http://www.leaddiscovery.co.uk/trials/6940?34 http://www.leaddiscovery.co.uk/trials/6940 Thu, 11 Mar 2010 21:19:52 GMT Dose Finding Study of BI 6727 in Patients With Various Solid Cancers http://www.leaddiscovery.co.uk/trials/6936?35 http://www.leaddiscovery.co.uk/trials/6936 Thu, 11 Mar 2010 21:19:52 GMT Panobinostat (LBH589) Plus Everolimus (RAD001) in Patients With Relapsed and Refractory Lymphoma