DailyUpdates from LeadDiscovery: Breaking Research, Development News and Pharmareports for Drug Discovery http://www.leaddiscovery.co.uk Dedicated to drug discovery, LeadDiscovery was founded in 1998 by life scientists for life scientists. Fri, 03 Jul 2009 18:34:38 GMT DailyUpdates http://www.leaddiscovery.co.uk Breaking Research, Development News and Pharmareports for Drug Discovery http://www.leaddiscovery.co.uk/dailyupdates_RSS_Icon.gif 144 59 http://www.leaddiscovery.co.uk/articles/19509160/dailyupdate?1 http://www.leaddiscovery.co.uk/articles/19509160/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Antitumor effects and biomarkers of activity of AZD0530 a Src inhibitor in pancreatic cancer. http://www.leaddiscovery.co.uk/articles/19423348/dailyupdate?2 http://www.leaddiscovery.co.uk/articles/19423348/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Analysis of HIF - 1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations. http://www.leaddiscovery.co.uk/articles/19493273/dailyupdate?3 http://www.leaddiscovery.co.uk/articles/19493273/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib. http://www.leaddiscovery.co.uk/articles/19409643/dailyupdate?4 http://www.leaddiscovery.co.uk/articles/19409643/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Feasibility study of postoperative adjuvant chemotherapy with S-1 (tegaful gimeracil oteracil potassium) for non-small cell lung cancer-LOGIK 0601 study. http://www.leaddiscovery.co.uk/articles/19409773/dailyupdate?5 http://www.leaddiscovery.co.uk/articles/19409773/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Phase III study of S-1 plus carboplatin in patients with advanced non-small cell lung cancer. http://www.leaddiscovery.co.uk/articles/19415165/dailyupdate?6 http://www.leaddiscovery.co.uk/articles/19415165/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Quality of life and seizure control in patients with brain tumor-related epilepsy treated with levetiracetam monotherapy: preliminary data of an open-label study. http://www.leaddiscovery.co.uk/articles/19507860/dailyupdate?7 http://www.leaddiscovery.co.uk/articles/19507860/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Generation of Ligand - Based Pharmacophore Model and Virtual Screening for Identification of Novel Tubulin Inhibitors with Potent Anticancer Activity. http://www.leaddiscovery.co.uk/articles/19492024/dailyupdate?8 http://www.leaddiscovery.co.uk/articles/19492024/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT The Influence of Endocrine Disrupting Chemicals on the Proliferation of ERalpha Knockdown-Human Breast Cancer Cell Line MCF-7 New Attempts by RNAi Technology. http://www.leaddiscovery.co.uk/articles/19509148/dailyupdate?9 http://www.leaddiscovery.co.uk/articles/19509148/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Anti-EMMPRIN monoclonal antibody as a novel agent for therapy of head and neck cancer. http://www.leaddiscovery.co.uk/articles/19509164/dailyupdate?10 http://www.leaddiscovery.co.uk/articles/19509164/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT The monoclonal antibody nBT062 conjugated to cytotoxic Maytansinoids has selective cytotoxicity against CD138-positive multiple myeloma cells in vitro and in vivo. http://www.leaddiscovery.co.uk/articles/19419878/dailyupdate?11 http://www.leaddiscovery.co.uk/articles/19419878/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Design synthesis and biological investigation of certain pyrazole - 3 - carboxylic acid derivatives as novel carriers for nitric oxide. http://www.leaddiscovery.co.uk/articles/19494493/dailyupdate?12 http://www.leaddiscovery.co.uk/articles/19494493/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Inhibition of Matrix Metalloproteinase-9 with Doxycycline Reduces Pancreatitis-Associated Lung Injury. http://www.leaddiscovery.co.uk/articles/19425829/dailyupdate?13 http://www.leaddiscovery.co.uk/articles/19425829/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT In Vivo Performance Testing of the Novel Medspray((R)) Wet Aerosol Inhaler. http://www.leaddiscovery.co.uk/articles/19403889/dailyupdate?14 http://www.leaddiscovery.co.uk/articles/19403889/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Imatinib for refractory chronic graft-versus-host-disease with fibrotic features. http://www.leaddiscovery.co.uk/articles/19494310/dailyupdate?15 http://www.leaddiscovery.co.uk/articles/19494310/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsis. http://www.leaddiscovery.co.uk/articles/19491826/dailyupdate?16 http://www.leaddiscovery.co.uk/articles/19491826/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT A Randomized Double-Blind Placebo-Controlled Trial of Rifaximin a Nonabsorbable Antibiotic in the Treatment of Tropical Enteropathy. http://www.leaddiscovery.co.uk/articles/19496999/dailyupdate?17 http://www.leaddiscovery.co.uk/articles/19496999/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Dopamine D(23) receptor binding potential and occupancy in midbrain and temporal cortex by haloperidol olanzapine and clozapine. http://www.leaddiscovery.co.uk/articles/19425168/dailyupdate?18 http://www.leaddiscovery.co.uk/articles/19425168/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Inactivation of sodium channels underlies reversible neuropathy during critical illness in rats. http://www.leaddiscovery.co.uk/articles/19508825/dailyupdate?19 http://www.leaddiscovery.co.uk/articles/19508825/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Attenuation of ischemia-induced rat brain injury by 2-(-2-benzofuranyl)-2-imidazoline a high selectivity ligand for imidazoline I(2) receptors. http://www.leaddiscovery.co.uk/articles/19508464/dailyupdate?20 http://www.leaddiscovery.co.uk/articles/19508464/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Effect of ezetimibesimvastatin compared with atorvastatin on lipoprotein subclasses in patients with type 2 diabetes and hypercholesterolaemia. http://www.leaddiscovery.co.uk/articles/19509029/dailyupdate?21 http://www.leaddiscovery.co.uk/articles/19509029/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT SGLT1 is a Novel Cardiac Glucose Transporter that is Perturbed in Disease States. http://www.leaddiscovery.co.uk/articles/19508393/dailyupdate?22 http://www.leaddiscovery.co.uk/articles/19508393/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Treatment with the K(v)7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. http://www.leaddiscovery.co.uk/articles/19493440/dailyupdate?23 http://www.leaddiscovery.co.uk/articles/19493440/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Myoglobin over-expression attenuates angiogenic response in hindlimb ischemia in mice. http://www.leaddiscovery.co.uk/articles/19509167/dailyupdate?24 http://www.leaddiscovery.co.uk/articles/19509167/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Suppression of HER2HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor trastuzumab and pertuzumab. http://www.leaddiscovery.co.uk/articles/19491021/dailyupdate?25 http://www.leaddiscovery.co.uk/articles/19491021/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Amphotericin B-entrapping lipid nanoparticles and their in vitro and in vivo characteristics. http://www.leaddiscovery.co.uk/articles/19496531/dailyupdate?26 http://www.leaddiscovery.co.uk/articles/19496531/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Safety and immunogenicity of a human and mouse gp100 DNA vaccine in a phase I trial of patients with melanoma. http://www.leaddiscovery.co.uk/articles/19508713/dailyupdate?27 http://www.leaddiscovery.co.uk/articles/19508713/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Chemokine receptor CXCR4 expression in hepatocellular carcinoma patients increases the risk of bone metastases and poor survival. http://www.leaddiscovery.co.uk/articles/19509137/dailyupdate?28 http://www.leaddiscovery.co.uk/articles/19509137/dailyupdate Fri, 03 Jul 2009 18:34:36 GMT Electrochemical Sensor for Multiplex Biomarkers Detection. http://www.leaddiscovery.co.uk/news/4811?29 http://www.leaddiscovery.co.uk/news/4811 Fri, 03 Jul 2009 18:34:37 GMT Provectus Completes Patient Accrual in Phase 2 Trial of PV-10 for Metastatic Melanoma http://www.leaddiscovery.co.uk/news/5125?30 http://www.leaddiscovery.co.uk/news/5125 Fri, 03 Jul 2009 18:34:37 GMT Acura and King Receive FDA Complete Response Letter Regarding Acurox http://www.leaddiscovery.co.uk/trials/5453?31 http://www.leaddiscovery.co.uk/trials/5453 Fri, 03 Jul 2009 18:34:37 GMT Cisplatin and Paclitaxel in Treating Patients With Stage IIB Stage IIC Stage III or Stage IV Ovarian Epithelial Cancer Fallopian Tube Cancer or Primary Peritoneal Cavity Cancer http://www.leaddiscovery.co.uk/trials/5456?32 http://www.leaddiscovery.co.uk/trials/5456 Fri, 03 Jul 2009 18:34:37 GMT Bicalutamide With or Without Everolimus in Treating Patients With Recurrent or Metastatic Prostate Cancer http://www.leaddiscovery.co.uk/reports/175?33 http://www.leaddiscovery.co.uk/reports/175 Fri, 03 Jul 2009 18:34:37 GMT Drug Delivery in Cancer - technologies markets and companies http://www.leaddiscovery.co.uk/reports/176?34 http://www.leaddiscovery.co.uk/reports/176 Fri, 03 Jul 2009 18:34:37 GMT RNAi - technologies markets and companies http://www.leaddiscovery.co.uk/reports/177?35 http://www.leaddiscovery.co.uk/reports/177 Fri, 03 Jul 2009 18:34:37 GMT Gene Therapy - technologies markets and companies http://www.leaddiscovery.co.uk/reports/178?36 http://www.leaddiscovery.co.uk/reports/178 Fri, 03 Jul 2009 18:34:37 GMT Nanobiotechnologies- applications markets and companies http://www.leaddiscovery.co.uk/reports/179?37 http://www.leaddiscovery.co.uk/reports/179 Fri, 03 Jul 2009 18:34:37 GMT Drug Delivery in Central Nervous System Diseases - technologiesmarkets and companies